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The laboratory studies the physiology, regulation, and biophysics of potassium (K+) channels. These multipronged proteins are at the crossroad of multiple cellular functions including excitablity, proliferation and growth, survival, and death.
Current projects focus on elucidating the role of K+ channels in neurodevelopment, metabolic disorders, epilepsy Alzheimer's disease, and traumatic brain injury. We are also assessing the potential therapeutic of second-generation Bcr-Abl and Src tyrosine kinase inhibitors and BACE1 inhibitors for the treatment of those pathologies.
As part of a broader Rutgers–India international initiative, Dr. Sesti spent three months as a Visiting Professor at the Indian Institute of Science in Bangalore, hosted by Dr. Giriraj Sahu. During this period, he established numerous scientific contacts and collaborations in India, including an ongoing research collaboration between his laboratory and Dr. Sahu.
Farewell to Irene. After spending six months in the lab, Irene is returning to Italy. We will all miss her smile and kindness.
From left to right: Aniket, Anika, G. Anika B., Maria, Kiarah, Federico, Irene, and Sana at the farewell dinner.
Irene’s hard work is starting to pay off. Here, she is at the international TERMIS meeting in Spain, where she recently presented a poster highlighting the results of her research in the lab.
Anika, Aniket, and Carmen presented the posters “Targeting Neuroinflammation in Mutant Kv2.1-Associated Developmental and Epileptic Encephalopathies” and “The Role of the IKC–Leptin Receptor Complex in Cortical Neurodevelopment” at the Rising Star Undergraduate Research Symposium, as well as the poster “The Role of IKC–Leptin Receptors on Cortical Neuronal Morphology” at the APSA Mid-Atlantic Regional Meeting. Both events were sponsored by Rutgers.
Aniket presented a poster titled “The Role of the IKC–Leptin Receptor Complex in Cortical Neurodevelopment” at the National Collegiate Undergraduate Research Symposium at Harvard University.
In addition, Aniket, Anastasia, Maria del Carmen and Rachel were awarded Aresty Fellowships totaling $1,000 each—congratulations!
In addition, Aniket, Anastasia, Maria del Carmen and Rachel were awarded Aresty Fellowships totaling $1,000 each—congratulations!
A huge toast to Elena! 🥂 She graduated first in her class in Neuroscience—an outstanding achievement we’re all incredibly proud of. Elena successfully defended her thesis, “Tripartite IKC–Leptin Receptor Complexes Connect Physiological Neurodevelopment, Endocrine Signaling, and Its Disruption in Developmental and Epileptic Encephalopathies.”Congratulations, Elena, from the entire lab!!! 🎉
Anastasia was selected to give a flash talk and presented a poster at the 11th symposyum of the Rutgers Brain Health Institute on December 3rd 2025.
Srinidi has developed a software using OpenCV (an open sourced computer vision library) for counting cells utilizing watershed segmentation algorithm. This software can be accessed via the 'SOFTWARE' tab of this website.